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This was accompanied by upregulation of inducible nitric oxide synthase (iNOS), IL-1, and TNF-, and downregulation of arginase 1 (Arg-1), IL-10, and transforming growth factor-beta (TGF-)

58 Deficiency of these enzymes results in elevated levels of neurodegenerative diseases

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There have been isolated reports of reversible hepatic injury following intravenous glutathione administration, emphasizing the need for careful monitoring, especially with repeated or high-dose therapy

Prompt parenteral administration of vitamin B 12 prevents progression of neurologic damage