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available over-the-counter or on prescription Liraglutide (Saxenda) : A once-daily injectable GLP-1 receptor agonist, recommended by NICE (TA664) for use in specialist weight management services for a maximum of 2 years Semaglutide (Wegovy) : A once-weekly injectable GLP-1 receptor agonist, recommended by NICE (TA875) for use in specialist weight management services for a maximum of 2 years Naltrexone/bupropion (Mysimba) : Licensed in the UK but not routinely recommended by NICE for NHS use [11] Patients interested in obesity treatment should contact their GP for initial assessment

Trial participants on the highest dose lost roughly 15% of body weight over 68 weeks, a number so far above what any prior pharmacotherapy had achieved that endocrinologists who had spent careers managing modest expectations had to recalibrate the conversation in real time

Regular Medical Check-ups: Regular follow-ups with a healthcare provider can help monitor the effects of semaglutide on overall health, including the gallbladder

doi: 10.4178/epih.e2018043 379 McFarlandLVGohS

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A review published in 2025 found that significant weight regain occurred after 8 weeks of stopping weight loss medication