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Recent studies have identified a critical role for an enzyme (phosphatidic acid phosphatase, PAP1) involved in overall triglyceride and phospholipid homeostasis as a critical target of the PPAR signaling pathway

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(2016) 5:e105

Finally, a number of factors independent of epidemiological evidence point toward a causal role of early exposure to APAP in the induction of neurodevelopmental disorders, particularly ASD [2,3].Other objections to the conclusion that early exposure to APAP causes ASD in susceptible children include the fact that an association does not prove causation [40]

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