In vivo Assessment of Drug Interactions Empagliflozin pharmacokinetics were similar with and without coadministration of metformin, glimepiride, pioglitazone, sitagliptin, linagliptin, warfarin, verapamil, ramipril, and simvastatin in healthy volunteers and with or without coadministration of hydrochlorothiazide and torsemide in patients with type 2 diabetes mellitus (see Figure 1)
Reference link (FDA label PDF): Other narrow therapeutic index medicines (where small changes in absorption can matter) may warrant extra attention depending on the patient (examples often discussed for the GLP-1 class include warfarin or digoxinmonitoring decisions should be individualized)
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Pharmacokinetics and pharmacodynamiceffects of the oral DPP-4 inhibitor sitagliptin in middle-aged obese subjects
Single nucleotide polymorphism in the gene leading to an Arg 213 His amino acid substitution is relatively frequent in the Caucasian population (25.436.5%) (Glatt & Meinl, 2004)