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Semaglutide led to a significant reduction in HbA1c levels compared to placebo- Patients receiving semaglutide experienced significant weight loss compared to those on placebo PIONEER Trials (Peptide Innovation for Early Diabetes Treatment): The PIONEER (Peptide Innovation for Early Diabetes Treatment) trials were a series of global, randomized, controlled clinical trials that investigated the efficacy, safety, and tolerability of oral semaglutide, a GLP-1 receptor agonist, in patients with type 2 diabetes
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Compounded medications have not been reviewed by the FDA for safety, efficacy, or quality
Interestingly, these drugs also have a major benefit on cardiovascular disease outcomes and are approved to reduce major adverse cardiovascular events in type 2 DM patients with CV disease and independently in heart failure patients