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Notably, in contrast to 23 (HA08), a structurally very similar epimer (HA09) which differs only with regard to one stereogenic center and exhibiting a 100-fold lower affinity to IRAP did not affect spine morphology, indicating a correlation between the capacity to inhibit IRAP and a positive impact on DSD and spine morphology

Their regulation determines whether permeability remains controlled or becomes excessive

Irreversible and severe DNA damage in normal cells is typically eliminated via the apoptosis pathway 2

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