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Interestingly, a post-hoc analysis of the Prediabetes Lifestyle Intervention Study (PLIS) suggested that patients achieving prediabetes remission differed from non-responders in improvement in whole body insulin sensitivity, visceral adipose tissue (VAT) and intrahepatic fat rather than insulin secretion upon a similar weight loss 76

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Endotoxin administered into isolated rat hypothalamus led to generation of NO and CO, which subsequently led to significant decrease in CRH and vasopressin secretion (107)