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However, due to logistic challenges in assessing this endpoint, we have focused primarily on the differences between treatments in terms of plasma glucose iAUC following intraduodenal glucose infusion

This reduced IGFBP binding extends estimated half-life in animal studies to approximately 20 to 30 hours versus minutes to a few hours for native IGF-1

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The parallel is not exact, but it provides a plausible biological explanation for why some patients experience reduced sexual desire on GLP-1 therapy

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