The authors compare multiple senolytic strategies including FOXO4-DRI, dasatinib plus quercetin, navitoclax, and fisetin, evaluating mechanisms of action, selectivity profiles, and safety considerations for each approach
Brown adipose tissue transplantation ameliorates polycystic ovary syndrome
Enterobactin inhibits microbiota-dependent activation of AhR to promote bacterial sepsis in mice
Morning light to help stabilize cortisol A 10 to 12 hour eating window to support hormonal rhythm High-SCFA foods such as resistant starch, fiber, and polyphenols Oral-gut synbiotics to help restore pathway timing Better sleep to reduce reward-driven eating Protein and fiber meals to support GLP-1 cycles Alongside these habits, some people also consider gut-based GLP-1 support as one part of a broader microbiome and lifestyle approach, not as a replacement for the basics above
Although such interactions have been observed for quite some time, their effect on cancer cell biology is only recently being investigated in quite detail
Kelly et al