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Another study also found that acylcarnitine C3:0 was decreased in the end-stage renal disease (ESRD) with depression than those without depression and C3:0 had a good ability to diagnose depression in the ESRD (AUC = 0.934) (42)

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However, the FDA-approved dosing does not require adjustment based on body weight alone, suggesting these differences are not clinically significant within the therapeutic range

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Similar patterns may occur with pharmacological weight loss, though specific data for semaglutide are lacking

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