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The likelihood that Cys 60 is the active Cys of the AKT CSD is supported by studies which demonstrate its modification in experiments on growth factor signaling (Antico Arciuch et al., 2009)

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Nat Commun 5:111 Brasil ADA, Carvalho MDCD, Gerhardt E et al (2019) Characterization of the activity, aggregation, and toxicity of heterodimers of WT and ALS-associated mutant Sod1

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We focused on iron-regulatory proteins and found that Poly(rC)-binding protein 2 (PCBP2) was the top-ranked candidate (Fig