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ROS can induce single-strand and double-strand breaks in sperm DNA, as well as the formation of oxidative base lesions such as 8-hydroxy-2-deoxyguanosine (8-OHdG) (33, 34)

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Fecal microbiome analyses have found dysbiosis in ALS, though findings are not entirely consistent across studies (perhaps due to different diets and progression rates in patients) [212]