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Dosage and Frequency : Higher or more consistent dosing may enhance repair speed, while insufficient or irregular dosing can slow observable effects

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We excluded SLE and non-SLE RCTs with fewer than 15 and 50 patients in each arm, respectively, because they were unlikely to be able to detect sufficient HZ events [12]

The 12-month trial design enables us to assess senolytic-associated changes before and after treatment during the 3-month active treatment phase, track the reappearance of senescent cells after their removal during the 9-month post-treatment period, and evaluate disease trajectory differences over a one-year period (Figure 3)

Medications : Certain medications, including antidepressants, blood pressure medications, and steroids, can interfere with your sleep and contribute to insomnia

DDP4 : MERS