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Many people notice a scratchy or sore throat after a session, especially with frequent or heavy use

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Byron, noting that a similar product, called Quest Cigarettes, was on the market in the US from 2002-2010 but was discontinued due to poor sales

In 2019, the FDA awarded its first-ever reduced risk designation to a similar product: snus, a tobacco pouch popular in Sweden that contains lower levels of carcinogens than cigarettes

This suggests that chronic smoke exposure leads to an increase in smoke-mediated activation of the parthanatos pathway and implicates its contribution in the pathogenesis of smoke-related lung diseases