M.CoyleF.PrasadV.et al
In the STEP 1 extension trial, participants regained approximately two-thirds of their weight loss after stopping semaglutide
Semaglutide works by enhancing glucose dependent insulin secretion, suppressing excess glucagon release, and slowing gastric emptying, leading to sustained reduction in fasting and post meal blood glucose levels
pre prchu pomaran: E102, E110
Tirzepatide activates GLP-1 and GIP receptors in your brain to increase satiety signals, creating genuine fullness rather than willpower-based restriction
GLP-1 class: do not combine Combining semaglutide with other GLP-1 agonists (liraglutide, dulaglutide) or with GLP-1-containing multi-agonists (tirzepatide, retatrutide) risks unpredictable GLP-1 receptor overstimulation, compounded GI toxicity, and uncontrolled metabolic effects