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Tirzepatide (Mounjaro/Zepbound), which targets two of the three receptors Retatrutide hits, produces about 20.9% weight loss

Ozempic, primarily known as a diabetes medication, has recently raised concerns over potential health risks in clinical trials, particularly related to gastrointestinal and cardiovascular health

Astrocyte metabolism of the medium-chain fatty acids octanoic acid and decanoic acid promotes GABA synthesis in neurons via elevated glutamine supply

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It has poor quality of life and an increased incidence of premature death

PLoS One 13 (5), e0197486