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Procedure Steps Preoperative Preparation and Clinical Assessment Before initiating isotretinoin, clinicians obtain a detailed history of prior acne treatments, prior psychiatric or mood disorders, liver disease, hyperlipidemia, and concomitant medications that may interact with retinoid metabolism or increase teratogenic risk

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ES2 is a senolytic peptide that targets FOXO4 CR3 but exhibits relatively poorer selectivity for senescent cells compared to FOXO4-DRI 25 (Table S1)

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