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A: This injection is strictly for intravenous use and must be administered by a registered medical practitioner

First, an N-terminal 13-amino acid extension was added

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Pathological changes to the vascular tissue in the CNS have been observed since the earliest descriptions of MS (see, for example, [89, 108]), and they include platelet and fibrin deposits associated with vessels in active lesions, vessel occlusion, vascular thickening, enhanced deposition of perivascular collagen, BBB disruption, and perivascular inflammation [7, 8, 1416, 109]

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