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NHS patient guidance notes that such reactions are more likely during the first months of treatment while patients are still adjusting

A higher proportion of patients treated with tirzepatide achieved weight loss of 5% or greater (96% vs approximately 86%), 10% or greater (90% vs ~69%), and 15% or greater (78% vs ~50%)

doi:10.1016/j.jacc.2025.11.016 McGuire DK, Marx N, Mulvagh SL, et al

All nutritional counseling and behavioral therapy appointments are held virtually

This is why a strategy that only targets one piece, for example, eating smaller meals, often helps but does not eliminate the problem

Flexible options if circumstances change allow switching between compounded and branded medication if insurance coverage changes, adjusting doses or medication schedules, or pausing and restarting treatment as needed