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Combination therapies with other neuroprotective agents show potential

Preclinical and Clinical Applications of Melatonin in Neurodegenerative Diseases Generally accepted clinical research has shown that melatonin and its derivatives have a well-documented safety profile and are associated with minimal side effects when used as supplements or therapeutic agents for short-term periods (Bonomini et al

10.1016/j.tox.2016.08.016 118 Pogrmic-MajkicK.SamardzijaD.Stojkov-MimicN.VukosavljevicJ.Trninic-PjevicA.KopitovicV.et al (2018)

Classic symptoms The most recognizable symptom is a burning sensation in the chest that rises from the upper abdomen toward the throat

S., Wu, T., Young, R

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