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Retatrutide adopts a single continuous helix that penetrates the core of the receptor transmembrane domain (TMD) via its N-terminal segment (residues 113), while its C-terminal segment (residues 1430) interacts with the N-terminal -helix of the ECD, the extracellular tip of TM1 and ECL1 (Fig

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Food and Drug Administration (FDA) for diabetes treatment and not obesity