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Y250 is located much farther from the disulfide bonds (Cys128-Cys206 in the hinge region between K1 and K2 domains, and Cys211-Cys288, Cys232-Cys271, and Cys260-Cys283 in the K2 domain) than the distances between Y198 and disulfide bonds, Cys149-Cys189 and Cys177-Cys201

In summary, although there are many ways to activate the c-met signaling pathway to induce the occurrence of HCC, c-met expression and activation are indispensable

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The peptide also restores mucin production the protective glycoprotein layer separating gut bacteria from epithelial cells