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MGF differs structurally from IGF-1 LR3 and native IGF-1 by its unique E-domain sequence, which is associated with local tissue repair signaling rather than systemic growth effects

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When IGF-1 binds to receptors it primarily stimulates hypertrophy (increase in cell size) and hyperplasia (increase in cell number) in both children and adults

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Sermorelin supports and amplifies this nocturnal pulse without overriding the feedback loop meaning research subjects maintain physiological GH patterns rather than experiencing supraphysiological spikes