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4.2.2.2 Reduced Lactobacillus in OA: iron metabolism regulation and probiotic potential For patients with KOA, the abundance of Lactobacillus significantly decreased (Gaspar et al., 2025)

Initially observed in toxicology, where sub-toxic doses of certain chemicals paradoxically improved organismal function, the term hormesis was later coined to describe this broadly applicable phenomenon, encompassing cellular, molecular, and organismal levels

The data were analyzed using GraphPad Prism 9 (GraphPad Software, Inc.)

Yes, together they can provide the following cumulative benefits: Better gut health Good immune support Antioxidant protection

pH 37, citric acid/disodium hydrogen phosphate

Antibody-drug conjugates normally employ cytotoxic agents as payloads, but many of them are substrates of the efflux transporter MDR1, which is an important mechanism to generate drug resistance