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Biologics face slower erosion because interchangeability standards, formulary dynamics, and physician reluctance create friction that delays adoption

Cells were washed three times with ice-cold PBS and lysed in lysis buffer (40 mM Tris-HCl (pH 8.0), 1% Triton X-100, 1% NP-40, 10% glycerol, 0.15 M NaCl, 2 mM EDTA, 1 mM phenylmethanesulfonyl fluoride, 1 Complete protease inhibitor cocktail)

Efficacy of L-propionylcarnitine treatment in patients with left ventricular dysfunction

We used inverse-probability-of-censoring weights to address differential follow-up, and stabilized censoring weights were well behaved (few extremes), which helps explain why the confidence intervals are not excessively wide

The incidence of adverse events did not differ between the active treatment and placebo groups

La recomendacin de la agencia es condicional, lo que significa que los beneficios probablemente superen las desventajas, pero se necesita ms evidencia