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Weinbaum S, Tarbell JM, Damiano ER

Vascular endothelial dysfunction in aging: loss of Akt-dependent endothelial nitric oxide synthase phosphorylation and partial restoration by (R)-alpha-lipoic acid

The supplementary NAD+ dose is 100200 mg IM, two or three times weekly

Observed responses in research settings are generally mild and may include temporary administration-site irritation, redness, warmth sensations, local sensitivity, temporary itching, mild fatigue, or response variability depending on research amount, administration frequency, protocol duration, and individual sensitivity

Kretschmann, A

Your blood sugar drops without involving insulin at all