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In this experiment, in the obese mice group, the expression of muscle atrophy markers Atrogin-1 and MuRF-1 of C2C12 myotube cells increased, and the expression of myogenic differentiation markers (MyoD, Myogenin) and SIRT1 decreased
(2022) 2:e56
Methods: Male C57BL/6J mice were given standard diet (ND), high-fat diet (HFD), or high-fat diet with semaglutide (SHF, 100 g/kg)
Semaglutide works by imitating the GLP-1 hormone, which plays a role in managing appetite and blood sugar levels
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