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J Biol Chem 2002;277:4276942774 [DOI] [PubMed] [Google Scholar] 32
In laboratory research, it is utilized as a primary endogenous antioxidant to study the neutralization of reactive oxygen species (ROS) and the maintenance of cellular redox homeostasis
The model predicts that initial knock-down of Keap1 by siKEAP1 is counteracted by increasing Nrf2 concentrations, which subsequently upregulate Keap1 and Srxn1 mRNA production (Fig 3C)
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In the case of failure to fall asleep after receiving the first drug, it is useful to add the other (if the child does not fall asleep after Mel, it makes sense to give Dex and vice versa)
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