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Semaglutide is approved by the U.S

Upon ligand recognition, NOD1/2 recruits receptor-interacting serine/threonine-protein kinase 2 (RIPK2) via CARD-CARD interactions, which further mediates TAK1 recruitment and activation, followed by activation of NF-B and MAPK signaling, leading to transcriptional up-regulation of pro-inflammatory and host defense genes (8688)

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This is the same mechanism used in semaglutide and other long-acting GLP-1 drugs