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These gut microbiota-derived bile acid metabolites serve as signaling molecules that function as key regulators of systemic metabolism

Acknowledgements The authors acknowledge the efforts of Prof Omnia ElRashidy one of the founders of the Pediatric Ketoclinic and Prof Ehab Khairy Emam the Head of the Pediatric Gastroenterology, Hepatology and Clinical Nutrition Unit, at the children`s Hospital, Faculty of Medicine, Ain shams University, for their support

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Berberine alleviates pulmonary hypertension through Trx1 and -catenin signaling pathways in pulmonary artery smooth muscle cells