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Laryngologists are physicians who have completed a medical residency in otolaryngology (ENT) and have additionally completed a subspecialty in laryngology

Table 4 Recommendations for policymakers and healthcare systems

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This creates a design challenge: redox modulation must be targeted in space and time to avoid global suppression of ROS signaling, which may reduce therapeutic efficacy ( 4.2 Healthy-tissue antioxidant shielding and the antioxidant paradox Many standard therapies cause systemic oxidative injury (e.g., cardiotoxicity from anthracyclines), prompting antioxidant shielding strategies ( 4.3 Safety implications of dual redox programming The same formulation feature that is attractive for tumor sensitization, namely, prolonged intracellular residence or stimulus-linked release, can magnify liability when exposure occurs in non-target tissues