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Additionally, GCGR activation may indirectly influence fibrogenesis by modulating the hepatic metabolic milieu, reducing lipotoxicity and oxidative stress that serve as upstream triggers for fibrotic pathways (39, 47)
Restarting the medication helped restore some protection, but only partially, showing that discontinuation leaves a lasting scar. Healio previously reported that the discontinuation of GLP-1 receptor agonists was tied to weight regain and higher risks for some adverse pregnancy outcomes like gestational diabetes and preterm delivery
Even in early PD, unintentional weight loss is common, and this has been linked to sarcopenia, frailty, and accelerated disease progression [22,23,24]
Anti-inflammatory effects of resveratrol: mechanistic insights
