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Unexpectedly, the mouse model overexpressing MET was able to counteract this resistance to immunotherapy, and the tumor's expansion was markedly reduced when the MET inhibitor was used alongside the anti-PD-1 antibody

10.1126/science.1165946 191 WuL.XingP.LiJ

If they start to dip, it might be time to increase their frequency for a bit

Future longitudinal studies that correlate symptoms fluctuations with alterations in these pathways could also help identify new therapeutic targets

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