Growth-modulating serum tripeptide is glycyl-histidyl-lysine
Slowing the dose escalation schedule, temporarily returning to a lower dose, or holding at the current dose longer than recommended are options that can improve tolerability while still achieving therapeutic benefits
Referenced Citations Sikiric P, et al
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indicated specifically to treat GI side effects from GLP-1s
Newer compounds like retatrutide add a third receptor target (GIP, GLP-1, and glucagon) and may create unique nutritional challenges that have not yet been well-studied