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However, a significant clinical limitation of the MDRD eGFR was the recommendation to only report eGFRs below 60 mL/min/1.73 m 2

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for his review of the manuscript and helpful input prior to submission

However, therapeutic doses for treating deficiency range from high-dose oral supplements (1,0002,000 g daily) to intramuscular injections of 1 mg, particularly for pernicious anaemia or malabsorption conditions

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