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p53 TAD (13-61) was subcloned into the pET His 6 glutathione-S-transferase (GST) TEV LIC cloning vector (2G-T, obtained from Scotta Gradia, Addgene plasmid #29707) and transformed into BL21 (DE3) pLysS cells
The number reflects the binding proteins the assay measures, the platform that produced it, what the patient has been exposed to, and the clinical picture around it
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The extended half-life enables once-weekly subcutaneous dosing, which is the standard clinical approach [1]
Its a powerful theoretical synergy
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