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They can bind to free fatty acid receptors (FFARs) on immune cells, while butyrate, as a HDAC inhibitor, can upregulate the expression of anti-inflammatory genes and induce microglial polarization toward an anti-inflammatory phenotype (Zhao et al., 2022

Jan 2005;81(1):130-133

Although some marketing websites call it a peptide, it is chemically a small molecule derived from quinoline

AOD-9604 can be administered via subcutaneous injection or orally, depending on formulation