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While the efficacy data did not survive the Phase IIb primary endpoint, the safety dataset across 900 participants is unusual for a research peptide and is consistently cited as the basis for continued investigational interest

This gives us the opportunity to address the root cause of all three, rather than viewing them solely through the lens of association, as done with the biopsychosocial model

124 Low vitamin B12 levels and intake have been associated with increased risk of tinnitus in observational studies

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No significant inhibition of COMT, GNMT, or PNMT observed