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A study in patients with type 2 diabetes showed that liraglutide acutely increased urinary sodium excretion despite no change in atrial natriuretic peptide levels, confirming a natriuretic action in humans [24]

Evidence of this latter effect has been observed in vivo , yet more work is required to determine under which conditions these mechanisms occur

[DOI] [PubMed] [Google Scholar] 27.Vila M., Jackson-Lewis V., Gugan C., et al

July 13, 2014

[DOI] [PMC free article] [PubMed] [Google Scholar] Kamble SH, Sharma A, King TI, Len F, McCurdy CR, Avery BA (2019) Metabolite profiling and identification of enzymes responsible for the metabolism of mitragynine, the major alkaloid of Mitragyna speciosa (kratom)

Los agonistas del receptor del pptido similar al glucagn tipo 1 (GLP-1), como semaglutida (Ozempic, Wegovy), se prescriben ampliamente para el manejo de la diabetes tipo 2 y la obesidad