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However, it is worth noting that most preclinical studies do not incorporate a dose titration phase, a gradual increase to the therapeutic maintenance dose, which is standard in clinical settings

It should not be used during pregnancy for weight management and is not recommended in patients with severe gastrointestinal disease

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Stay on the lookout for side effects coming back or starting When you change dose, side effects may start, or they may return

This additional mechanism may explain why many patients experience faster and more significant weight loss with Tirzepatide versus Semaglutide

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