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In rodent knockout models where beta-3 adrenergic receptors were removed, the lipolytic response to AOD 9604 was eliminated, confirming the receptor-specific mechanism

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Endocrinology, 142(12), 51825189

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Fewer systemic side-effects compared to hGH Because AOD 9604 does not significantly elevate IGF-1 or impair glucose/insulin regulation (in trials), it may carry lower risk of some growth hormone-associated adverse effects