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The comparing between the amino acid sequences of GhGPXs and previously reported GPXs of other plant species revealed that redox centre embraced with a Cys residue (known to be a catalytic site) as well as Trp, Asn and Gln conserved residues 15 (Fig

ROS exacerbate the misfolding process, promoting the accumulation of protein aggregates near neuronal axons and dendrites, ultimately impairing synaptic communication [196]

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The activation of hGPX4-C by compound 102 were remarkably reduced for mutant D23A (the compound concentration required to reach 150% activation was higher than 2,500 M)