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If phase 3 trials confirm its promise, clinicians in the second half of this decade may have access to a tool that not only rivals surgery for weight loss, but also transforms the prognosis of diseases like metabolic liver disease and type 2 diabetes

Maximum Weight Loss Potential (Future) Amycretin Phase 1b/2a showed up to 24.3% weight loss at 36 weeks with no plateau, suggesting even greater loss with longer treatment

Short-Term Storage: Refrigeration below 4C (39F) is generally acceptable

Effective biomarkers, such as GPX4, 4-HNE, and MDA in joint fluid, can be used to monitor treatment response and assist in dose optimization (Table 2)