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Oral Glutathione has low bioavailability because digestive enzymes break it down, while IV administration provides 100% bioavailability directly into the bloodstream for immediate absorption

The prevalence of this CYP2D6 phenotype varies widely and has been estimated at 1 to 10% for Whites (European, North American), 3 to 4% for Blacks (African Americans), 1 to 2% for East Asians (Chinese, Japanese, Korean), and may be greater than 10% in certain racial/ethnic groups (i.e., Oceanian, Northern African, Middle Eastern, Ashkenazi Jews, Puerto Rican)

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Laboratory and animal research suggests that MOTS-c participates in cellular responses to metabolic stress