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The gain-of-function mutations of IDH1 and IDH2 genes commonly occur in GBM and acute myeloid leukemia (AML) and are associated with accelerated tumor cell proliferation and inhibited differentiation [75,76]

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The interaction of PLC with PIP2 activates the 2-hydroxy group of the inositol ring, which further attacks 1-phosphate, leading to the formation of 1,2-cyclic phosphate and DAG intermediates

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