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41 A multicenter phase II study (LEAN) demonstrated the efficacy of liraglutide (a GLP-1 agonist) in NASH resolution based on the disappearance of hepatocyte ballooning without fibrosis worsening among NASH patients after 48 weeks of treatment

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The drug is used in combination with Erbitux (cetuximab) and fluorouracil-based chemotherapy to treat adults with metastatic colorectal cancer carrying a BRAF V600E mutation

Evolution of GLP-1-Based Therapeutics The therapeutic use of GLP-1RAs has evolved significantly, offering various formulations that provide different efficacy, administration routes, and dosing flexibility [19] [20]

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