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In line, hepatic expression of LIGHT, HVEM, and LTR was increased in mice fed a high-fat high-cholesterol diet (HFHCD) compared to WT mice, whereas LIGHT deficiency ( light / ) in mice on HFHCD resulted in lower IR and hepatic steatosis and reduced hepatic, adipose tissue, and systemic inflammation compared to WT mice under the same diet (HFHCD) [53]

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