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138 The dose-response trial also lacked a placebo control group and reported at eight months no differences in proportions of patients experiencing clinically significant improvements (300 mg daily 50%

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Early clinical trials in diabetic patients have indicated that GLP-1RAs treatment is associated with improvements in health-related quality of life and well-being compared with insulin and sulfonylureas

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Mechanistically, in macrophages, GLP-1RAs directly ameliorate NF-B activation, thereby improving insulin resistance [132]

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