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Tirzepatide is contraindicated in patients with a personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2, and in those with serious hypersensitivity to tirzepatide or its excipients

Other research has found that GLP-1 receptor agonists did not increase suicide risk and that semaglutide may be linked to lower suicidal ideation risk than other obesity or diabetes drugs

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Others might transition to non-GLP-1 medications like phentermine to help sustain their progress

It was developed as a twice-daily therapy [19] and was approved by the US Food and Drug Administration (FDA) in 2005 and by the European Medicines Agency (EMA) in 2006