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We provide evidence here for the importance of recycling via our studies with BETP, which reduced recycling without affecting acute signaling or endocytosis, and accordingly reduced exendin-4-induced insulin secretion

Some of the predicted drug targets by our refined workflow, namely HMGCR, FASN and SQLE are key regulators of cholesterol and lipid homeostasis

It mimics the function of GLP-1, a naturally occurring hormone that regulates peoples insulin production and slows down their digestion

Pharmacological inhibition of ferroptosis as a therapeutic target for sepsis-associated organ damage

This association remained robust across all subgroups examined, included both male and female patients, smokers and non-smokers, and those with varying body weights or blood pressure statuses, which indicated that the bone-protective effects of GLP-1 RAs were broadly applicable and not limited to specific patient profiles